[Seminariosifibyne] CICLO SEMINARIOS IFIBYNE- FBMC 2022 - Agosto

[Comunicación IFIBYNE]

Dentro del ciclo de actividades IFIBYNE 2022 presentamos los próximos
Seminarios organizados por el IFIBYNE y el FBMC que se desarrollaran en
el auditorio del nuevo espacio cultural del Instituto. 
 Podrán ver la información actualizada en la sección "Seminarios" de la
página web https://ifibyne.fcen.uba.ar/seminarios-2 
 Contamos con la presencia de toda la comunidad IFIBYNE 

 VIERNES 12 DE AGOSTO, 12:00 HORAS - AUDITORIO IFIBYNE 
 Presencial - Seminario Invitados - Ingreso libre con acreditación
previa 
 Coordina: Alejandro Delorenzi 
 Contacto IFIBYNE: Fernando Locatelli - locatellif at fbmc.fcen.uba.ar 
 Contacto FBMC: Mariana Feld -  feld.mariana at gmail.com 

 KENNETH LUKOWIAK 
 Hotchkiss Brain Institute 
 Department of Physiology and Pharmacology 
 University of Calgary, CANADA 
 https://bit.ly/3SHnny7 

 "THE MANY FORMS OF MEMORY IN LYMNAEA. WHY WE SHOULD BE INTERESTED IN
ALL OF THEM" 

 xperiments starting in 1986 demonstrated that long-term memory
formation (LTM, i.e., a memory lasting at least 24h) occurs following
operant conditioning of a very tractable Lymnaea  behaviour -aerial
respiration. Experiments that followed showed that a single neuron was a
necessary site for LTM. It was then shown that even a single event (i.e.
one-trial learning-1TT) using aerial respiration could result in LTM
formation. We went on to show that various ecologically relevant
stressors could alter the formation of LTM and its duration. Some
stressors blocked LTM formation while others enhanced it. Stressors
could also alter the ability to recall a formed LTM, something we did
not expect. Using another tractable behaviour feeding we have now been
able to demonstrate different forms of conditioned taste aversion (CTA).
Interestingly, LTM of CTA can be produced by a single training event.
More recently, using this behaviour we have been able to demonstrate a
'higher form of learning and memory-Configural Learning (CL). To cause
CL Lymnaea experience a food taste at the same time with a predator
scent. Snails now do not eat the substance they encountered with the
predator scent. More importantly training snails in the scent of the
food alters LTM formation of a behaviour (aerial respiration) that was
not encountered in the CL procedure. Finally, we have now demonstrated a
Garcia-effect' in Lymnaea. When they eat a novel food substance and then
are made sick hours later (either by a heat shock or LPS injection) they
now avoid that food. However, this only works with a novel food taste.
We are now, using the Garcia-effect training procedure to find whether
even a 5 minute exposure to a novel food substance is sufficient to
produce a LTM of the new taste such that even 2 weeks later the
food-taste is no longer capable of producing a Garcia-effect Finally, we
are now able to demonstrate changes in the mRNA associated with these
various memory states.

 -------------------

 VIERNES 19 DE AGOSTO, 12:00 HORAS - AUDITORIO IFIBYNE 
 Presencial - Seminario Invitados - Ingreso libre con acreditación
previa 
 Coordinan: Valentina Salzman y Esteban Beckwith @esteban_beckwith 
 Contacto IFIBYNE: vsalzman at iibintech.com.ar - estebanbeck at gmail.com 
 Contacto FBMC: Mariana Feld -  feld.mariana at gmail.com 

 ESTEBAN MAZZONI 
 Department of Biology, Neuroscience Institute, New York University 
 web: https://www.mazzonilab.org                        

 "MECANISMOS DE DIFERENCIACIÓN Y MEMORIA EPIGENÉTICA DE GENES HOX
DURANTE LA DIFERENCIACIÓN CELULAR" 

 Dos procesos conviven durante la diferenciación de motoneuronas y
generan la variedad de neuronas necesaria para el funcionamiento de la
espina dorsal: rápida regulación génica que guía la diferenciación y una
memoria epigenética estable que mantiene la posición celular eje
anteroposterior. Para entender estos procesos, hemos desarrollado
tecnologías nuevas que combinan la diferenciación de células madres,
screens genéticos y la construcción de elementos genéticos sintéticos de
gran tamaño. Finalmente, utilizamos estos conocimientos para generar
motoneuronas con distinta susceptibilidad a la neurodegeneración para
identificar los mecanismos que protegen a ciertas neuronas de la
degeneración.

--
-------------- next part --------------
An HTML attachment was scrubbed...
URL: http://cerebro.fbmc.fcen.uba.ar/pipermail/seminariosifibyne/attachments/20220805/1310aa00/attachment-0001.html 
-------------- next part --------------
A non-text attachment was scrubbed...
Name: 4706effc.png
Type: image/png
Size: 10459 bytes
Desc: not available
Url : http://cerebro.fbmc.fcen.uba.ar/pipermail/seminariosifibyne/attachments/20220805/1310aa00/attachment-0003.png 
-------------- next part --------------
A non-text attachment was scrubbed...
Name: 12-8-22.png
Type: image/png
Size: 1791742 bytes
Desc: not available
Url : http://cerebro.fbmc.fcen.uba.ar/pipermail/seminariosifibyne/attachments/20220805/1310aa00/attachment-0004.png 
-------------- next part --------------
A non-text attachment was scrubbed...
Name: 19-8-22.png
Type: image/png
Size: 2037678 bytes
Desc: not available
Url : http://cerebro.fbmc.fcen.uba.ar/pipermail/seminariosifibyne/attachments/20220805/1310aa00/attachment-0005.png