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<p><span style="font-family: verdana, geneva, sans-serif;">Dentro del ciclo de actividades IFIBYNE 2022 presentamos los próximos Seminarios organizados por el IFIBYNE y el FBMC que se desarrollaran en el auditorio del nuevo espacio cultural del Instituto.</span><br /><span style="font-family: verdana, geneva, sans-serif;">Podrán ver la información actualizada en la sección "Seminarios" de la página web <a href="https://ifibyne.fcen.uba.ar/seminarios-2" target="_blank" rel="noreferrer">https://ifibyne.fcen.uba.ar/seminarios-2</a></span><br /><span style="font-family: verdana, geneva, sans-serif;">Contamos con la presencia de toda la comunidad IFIBYNE</span><br /><br /><span style="font-family: verdana, geneva, sans-serif;"><strong>VIERNES 12 DE AGOSTO, 12:00 Horas - Auditorio IFIBYNE</strong></span><br /><span style="font-family: verdana, geneva, sans-serif;">Presencial - Seminario Invitados - Ingreso libre con acreditación previa</span><br /><span style="font-family: verdana, geneva, sans-serif;">Coordina: Alejandro Delorenzi</span><br /><span style="font-family: verdana, geneva, sans-serif;">Contacto IFIBYNE: Fernando Locatelli - <a href="mailto:locatellif@fbmc.fcen.uba.ar" rel="noreferrer">locatellif@fbmc.fcen.uba.ar</a></span><br /><span style="font-family: verdana, geneva, sans-serif;">Contacto FBMC: Mariana Feld - <a href="mailto:feld.mariana@gmail.com" rel="noreferrer">feld.mariana@gmail.com</a></span><br /><br /><span style="font-family: verdana, geneva, sans-serif;"><strong>Kenneth Lukowiak</strong></span><br /><span style="font-family: verdana, geneva, sans-serif;">Hotchkiss Brain Institute</span><br /><span style="font-family: verdana, geneva, sans-serif;">Department of Physiology and Pharmacology</span><br /><span style="font-family: verdana, geneva, sans-serif;">University of Calgary, CANADA</span><br /><span style="font-family: verdana, geneva, sans-serif;"><a href="https://bit.ly/3SHnny7" target="_blank" rel="noreferrer">https://bit.ly/3SHnny7</a></span><br /><br /><span style="font-family: verdana, geneva, sans-serif;"><strong>"The many forms of memory In Lymnaea. Why we should be interested in all of them"</strong></span><br /><br /><span style="font-family: verdana, geneva, sans-serif;">xperiments starting in 1986 demonstrated that long-term memory formation (LTM, i.e., a memory lasting at least 24h) occurs following operant conditioning of a very tractable Lymnaea behaviour -aerial respiration. Experiments that followed showed that a single neuron was a necessary site for LTM. It was then shown that even a single event (i.e. one-trial learning-1TT) using aerial respiration could result in LTM formation. We went on to show that various ecologically relevant stressors could alter the formation of LTM and its duration. Some stressors blocked LTM formation while others enhanced it. Stressors could also alter the ability to recall a formed LTM, something we did not expect. Using another tractable behaviour feeding we have now been able to demonstrate different forms of conditioned taste aversion (CTA). Interestingly, LTM of CTA can be produced by a single training event. More recently, using this behaviour we have been able to demonstrate a 'higher form of learning and memory-Configural Learning (CL). To cause CL Lymnaea experience a food taste at the same time with a predator scent. Snails now do not eat the substance they encountered with the predator scent. More importantly training snails in the scent of the food alters LTM formation of a behaviour (aerial respiration) that was not encountered in the CL procedure. Finally, we have now demonstrated a Garcia-effect' in Lymnaea. When they eat a novel food substance and then are made sick hours later (either by a heat shock or LPS injection) they now avoid that food. However, this only works with a novel food taste. We are now, using the Garcia-effect training procedure to find whether even a 5 minute exposure to a novel food substance is sufficient to produce a LTM of the new taste such that even 2 weeks later the food-taste is no longer capable of producing a Garcia-effect Finally, we are now able to demonstrate changes in the mRNA associated with these various memory states.</span><br /><br /><span style="font-family: verdana, geneva, sans-serif;">-------------------</span><br /><br /><span style="font-family: verdana, geneva, sans-serif;"><strong>VIERNES 19 DE AGOSTO, 12:00 Horas - Auditorio IFIBYNE</strong></span><br /><span style="font-family: verdana, geneva, sans-serif;">Presencial - Seminario Invitados - Ingreso libre con acreditación previa</span><br /><span style="font-family: verdana, geneva, sans-serif;">Coordinan: Valentina Salzman y Esteban Beckwith @esteban_beckwith</span><br /><span style="font-family: verdana, geneva, sans-serif;">Contacto IFIBYNE: <a href="mailto:vsalzman@iibintech.com.ar" rel="noreferrer">vsalzman@iibintech.com.ar</a> - <a href="mailto:estebanbeck@gmail.com" rel="noreferrer">estebanbeck@gmail.com</a></span><br /><span style="font-family: verdana, geneva, sans-serif;">Contacto FBMC: Mariana Feld - <a href="mailto:feld.mariana@gmail.com" rel="noreferrer">feld.mariana@gmail.com</a></span><br /><br /><span style="font-family: verdana, geneva, sans-serif;"><strong>Esteban Mazzoni</strong></span><br /><span style="font-family: verdana, geneva, sans-serif;">Department of Biology, Neuroscience Institute, New York University</span><br /><span style="font-family: verdana, geneva, sans-serif;">web: <a href="https://www.mazzonilab.org/" target="_blank" rel="noreferrer">https://www.mazzonilab.org</a> </span><br /><br /><span style="font-family: verdana, geneva, sans-serif;"><strong>"Mecanismos de diferenciación y memoria epigenética de genes Hox durante la diferenciación celular"</strong></span><br /><br /><span style="font-family: verdana, geneva, sans-serif;">Dos procesos conviven durante la diferenciación de motoneuronas y generan la variedad de neuronas necesaria para el funcionamiento de la espina dorsal: rápida regulación génica que guía la diferenciación y una memoria epigenética estable que mantiene la posición celular eje anteroposterior. Para entender estos procesos, hemos desarrollado tecnologías nuevas que combinan la diferenciación de células madres, screens genéticos y la construcción de elementos genéticos sintéticos de gran tamaño. Finalmente, utilizamos estos conocimientos para generar motoneuronas con distinta susceptibilidad a la neurodegeneración para identificar los mecanismos que protegen a ciertas neuronas de la degeneración.</span></p>
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