[Todos FBMC] Seminario QB: Fineran 11/10 12.30 hs

SEMINARIOS QB seminarios en qb.fcen.uba.ar
Mar Oct 10 12:16:41 ART 2017


Estimados colegas,

En el marco del curso Bacteriófagos: del genoma al metagenoma, el
miércoles 11/10 a las 12.30 hs en el aula Cardini el Dr. Peter Finerán
dará un seminario especial titulado: "The regulation and defence
activities of Class 1 CRISPR-Cas systems"

Bacteria have evolved ‘immune systems’ as a result of their constant
exposure to foreign mobile genetic elements, including bacteriophages and
plasmids. For example, an estimated 1025 bacteriophage infections occur
every second, which affects global nutrient cycles. Other mobile genetic
elements harbour antibiotic resistance or pathogenicity determinants,
which influence bacterial evolution and our ability to treat infectious
disease. To thwart these invaders, bacteria have many resistance
strategies, including adaptive immunity provided by the CRISPR-Cas
systems. In this talk I will present our recent research into how these
systems acquire spacers from their invaders and will explain how bacteria
use communication to regulate their CRISPR-Cas adaptive immune systems.

El Dr. Fineran es Profesor Asociado en Department of Microbiology and
Immunology, University of Otago, Dunedin, New Zealand y ha sido orador
invitado en los congresos más importantes sobre CRISPR-Cas. No se pierdan
esta ocasión de escucharlo!

Publicaciones seleccionadas:
-Spacer capture and integration by a type I-F Cas1-Cas2-3 CRISPR
adaptation complex. Fagerlund RD, Wilkinson ME, Klykov O, Barendregt A,
Pearce FG, Kieper SN, Maxwell HWR, Capolupo A, Heck AJR, Krause KL,
Bostina M, Scheltema RA, Staals RHJ, Fineran PC. Proc Natl Acad Sci U S
A.2017
-CRISPR-Cas: Adapting to change. Jackson SA, McKenzie RE, Fagerlund RD,
Kieper SN, Fineran PC, Brouns SJ. Science. 2017
-Regulation of CRISPR-Cas adaptive immune systems. Patterson AG,
Yevstigneyeva MS, Fineran PC. Curr Opin Microbiol. 2017
-Quorum Sensing Controls Adaptive Immunity through the Regulation of
Multiple CRISPR-Cas Systems. Patterson AG, Jackson SA, Taylor C, Evans
GB,Salmond GP, Przybilski R, Staals RH, Fineran PC. Mol Cell. 2016
-Interference-driven spacer acquisition is dominant over naive and primed
adaptation in a native CRISPR-Cas system. Staals RH, Jackson SA, Biswas A,
Brouns SJ, Brown CM, Fineran PC. Nat Commun. 2016

Contacto: seminarios en qb.fcen.uba.ar
Seminarios libres y sin inscripción previa


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Sub-Comisión Organizadora de Seminarios:
Dra.Alaimo, Dr.Bueno, Dr. Craig, Dra.Erlejman Dra.Kristoff

www.qb.fcen.uba.ar
Departamento de Química Biológica
Facultad de Ciencias Exactas y Naturales
Universidad de Buenos Aires.

4to Piso - Aula Cardini
Intendente Güiraldes 2160 - Pabellon II
Ciudad Universitaria
Buenos Aires - Argentina


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