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<p class="MsoNormal" style="margin-bottom: 0.0001pt; font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-fareast-font-family:&quot;Times New Roman&quot;;
mso-bidi-font-family:Arial;color:black;mso-ansi-language:ES-TRAD;mso-fareast-language:
EN-US">El laboratorio de Biología de Sistemas Moleculares del IFIBYNE (FCEN-UBA)
busca un estudiante de licenciatura en biología, química o carreras afines para
realizar la tesina de licenciatura (o equivalente) durante el 2011 y que esté
en condiciones de presentarse a beca doctoral CONICET este año, para comenzar
en 2012. </span></p>

<p class="MsoNormal" style="margin-bottom: 0.0001pt; font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-fareast-font-family:&quot;Times New Roman&quot;;
mso-bidi-font-family:Arial;color:black;mso-ansi-language:ES-TRAD;mso-fareast-language:
EN-US"> </span></p>

<p class="MsoNormal" style="margin-bottom: 0.0001pt; font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-fareast-font-family:&quot;Times New Roman&quot;;
mso-bidi-font-family:Arial;color:black;mso-ansi-language:ES-TRAD;mso-fareast-language:
EN-US">El interés general del laboratorio es entender los mecanismos que llevan
a “decisiones de destino celular” (“cell fate decisions”). Si bien estudiamos
los detalles de los mecanismos moleculares, nos interesa principalmente explicar
a nivel del sistema los comportamientos que causan estas decisiones. Estos
comportamientos resultan comúnmente de la interacción de un número relativamente
grande de componentes, por lo que en general resulta difícil comprender su
funcionamiento. Por eso, en el laboratorio combinamos experimentación
cuantitativa con simulaciones matemáticas, con el objetivo de derivar reglas
generales. Esto es lo que corrientemente se conoce como <span style="mso-bidi-font-style:
italic">enfoque de biología de sistemas</span>. Mayormente utilizamos como
modelo a la levadura <i>Saccharomyces cerevisiae.</i></span></p>

<p class="MsoNormal" style="margin-bottom: 0.0001pt; font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-fareast-font-family:&quot;Times New Roman&quot;;
mso-bidi-font-family:Arial;color:black;mso-ansi-language:ES-TRAD;mso-fareast-language:
EN-US"> </span></p>

<p class="MsoNormal" style="margin-bottom: 0.0001pt; font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-fareast-font-family:&quot;Times New Roman&quot;;
mso-bidi-font-family:Arial;color:black;mso-ansi-language:ES-TRAD;mso-fareast-language:
EN-US">El estudiante se integrará en un proyecto enfocado en entender las bases
moleculares de un mecanismo de decisión de destino celular, la expresión génica
asimétrica dependiente del factor de transcripción Ace2 en levaduras. Los
mecanismo que resultan en expresión génica asimétrica son responsables de gran
parte de la diversidad celular presente en organismos multicelulares, y ha sido
descriptos en bacterias, levaduras, gusanos, moscas y mamíferos. En nuestro
caso particular, el mecanismo último que causa la asimetría en la actividad de
Ace2 no ha sido dilucidado aún y es en el laboratorio el tema central de una
tesis doctoral avanzada. (ver referencias para una descripción de la biología
del proceso en cuestión y tener una idea del enfoque del laboratorio).</span></p>

<p class="MsoNormal" style="margin-bottom: 0.0001pt; font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-fareast-font-family:&quot;Times New Roman&quot;;
mso-bidi-font-family:Arial;color:black;mso-ansi-language:ES-TRAD;mso-fareast-language:
EN-US"> </span></p>

<p class="MsoNormal" style="margin-bottom: 0.0001pt; font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-fareast-font-family:&quot;Times New Roman&quot;;
mso-bidi-font-family:Arial;color:black;mso-ansi-language:ES-TRAD;mso-fareast-language:
EN-US">El estudiante investigará la dinámica de transporte nuclear de dicho
factor y un posible mecanismo nuevo de regulación de la actividad
transcripcional. Se utilizarán enfoques de microscopía cuantitativa confocal,
biología molecular y modelado matemático. </span></p>

<p class="MsoNormal" style="margin-bottom: 0.0001pt; font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-fareast-font-family:&quot;Times New Roman&quot;;
mso-bidi-font-family:Arial;color:black;mso-ansi-language:ES-TRAD;mso-fareast-language:
EN-US"> </span></p>

<p class="MsoNormal" style="margin-bottom: 0.0001pt; font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-fareast-font-family:&quot;Times New Roman&quot;;
mso-bidi-font-family:Arial;color:black;mso-ansi-language:ES-TRAD;mso-fareast-language:
EN-US">No es necesario que los postulantes tengan conocimientos previos en
modelado matemático o programación. Sí es indispensable buena disposición para los
enfoques matemáticos y computacionales, y para el trabajo experimental.</span></p>

<p class="MsoNormal" style="margin-bottom: 0.0001pt; font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-fareast-font-family:&quot;Times New Roman&quot;;
mso-bidi-font-family:Arial;color:black;mso-ansi-language:ES-TRAD;mso-fareast-language:
EN-US"> </span></p>

<p class="MsoNormal" style="margin-bottom: 0.0001pt; font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-fareast-font-family:&quot;Times New Roman&quot;;
mso-bidi-font-family:Arial;color:black;mso-ansi-language:ES-TRAD;mso-fareast-language:
EN-US">Los interesados por favor envíen un CV actualizado al Dr. Alejandro
Colman Lerner (<a href="mailto:colman-lerner@fbmc.fcen.uba.ar">colman-lerner@fbmc.fcen.uba.ar</a>). En el cuerpo del mensaje por
favor incluir una breve explicación de por qué les interesaría incorporarse al
laboratorio.</span></p>

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mso-bidi-font-family:&quot;Times New Roman&quot;;mso-ansi-language:ES-TRAD;mso-fareast-language:
EN-US"> </span></p>

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ES-TRAD">Referencias:</span></p>

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<p class="MsoListParagraphCxSpFirst" style="margin-bottom:0in;margin-bottom:.0001pt;
mso-add-space:auto;text-indent:-.25in;mso-list:l0 level1 lfo1"><a name="_ENREF_1"><span style="font-family:Arial;mso-fareast-font-family:
Arial;color:black;mso-fareast-language:EN-US"><span style="mso-list:Ignore">1.<span style="font:7.0pt &quot;Times New Roman&quot;">    </span></span></span><span lang="ES-TRAD" style="font-family:Calibri;mso-bidi-font-family:Arial;color:black;
mso-ansi-language:ES-TRAD;mso-fareast-language:EN-US">Chernomoretz, A., Bush,
A., Yu, R., Gordon, A., and Colman-Lerner, A. (2008). Using Cell-ID 1.4 with R
for microscope-based cytometry. Current protocols in molecular biology / edited
by Frederick M Ausubel  et al<i> Chapter 14</i>, Unit 14 18.</span></a><span style="mso-bookmark:_ENREF_1"></span><span style="font-family:Arial;color:black;
mso-fareast-language:EN-US"></span></p>

<p class="MsoListParagraphCxSpMiddle" style="margin-bottom:0in;margin-bottom:
.0001pt;mso-add-space:auto;text-indent:-.25in;mso-list:l0 level1 lfo1"><a name="_ENREF_2"><span style="font-family:Arial;mso-fareast-font-family:
Arial;color:black;mso-fareast-language:EN-US"><span style="mso-list:Ignore">2.<span style="font:7.0pt &quot;Times New Roman&quot;">    </span></span></span><span lang="ES-TRAD" style="font-family:Calibri;mso-bidi-font-family:Arial;color:black;
mso-ansi-language:ES-TRAD;mso-fareast-language:EN-US">Colman-Lerner, A., Chin,
T.E., and Brent, R. (2001). Yeast Cbk1 and Mob2 activate daughter-specific
genetic programs to induce asymmetric cell fates. Cell<i> 107</i>,
739-750.</span></a><span style="mso-bookmark:_ENREF_2"></span><span style="font-family:Arial;color:black;mso-fareast-language:EN-US"></span></p>

<p class="MsoListParagraphCxSpMiddle" style="margin-bottom:0in;margin-bottom:
.0001pt;mso-add-space:auto;text-indent:-.25in;mso-list:l0 level1 lfo1"><a name="_ENREF_3"><span style="font-family:Arial;mso-fareast-font-family:
Arial;color:black;mso-fareast-language:EN-US"><span style="mso-list:Ignore">3.<span style="font:7.0pt &quot;Times New Roman&quot;">    </span></span></span><span lang="ES-TRAD" style="font-family:Calibri;mso-bidi-font-family:Arial;color:black;
mso-ansi-language:ES-TRAD;mso-fareast-language:EN-US">Colman-Lerner, A.,
Gordon, A., Serra, E., Chin, T., Resnekov, O., Endy, D., Pesce, C.G., and
Brent, R. (2005). Regulated cell-to-cell variation in a cell-fate decision
system. Nature<i> 437</i>, 699-706.</span></a><span style="mso-bookmark:
_ENREF_3"></span><span style="font-family:Arial;color:black;mso-fareast-language:
EN-US"></span></p>

<p class="MsoListParagraphCxSpMiddle" style="margin-bottom:0in;margin-bottom:
.0001pt;mso-add-space:auto;text-indent:-.25in;mso-list:l0 level1 lfo1"><a name="_ENREF_4"><span style="font-family:Arial;mso-fareast-font-family:
Arial;color:black;mso-fareast-language:EN-US"><span style="mso-list:Ignore">4.<span style="font:7.0pt &quot;Times New Roman&quot;">    </span></span></span><span lang="ES-TRAD" style="font-family:Calibri;mso-bidi-font-family:Arial;color:black;
mso-ansi-language:ES-TRAD;mso-fareast-language:EN-US">Gordon, A.,
Colman-Lerner, A., Chin, T.E., Benjamin, K.R., Yu, R.C., and Brent, R. (2007).
Single-cell quantification of molecules and rates using open-source
microscope-based cytometry. Nat Methods<i> 4</i>, 175-181.</span></a><span style="mso-bookmark:_ENREF_4"></span><span style="font-family:Arial;color:black;
mso-fareast-language:EN-US"></span></p>

<p class="MsoListParagraphCxSpMiddle" style="margin-bottom:0in;margin-bottom:
.0001pt;mso-add-space:auto;text-indent:-.25in;mso-list:l0 level1 lfo1"><a name="_ENREF_5"><span style="font-family:Arial;mso-fareast-font-family:
Arial;color:black;mso-fareast-language:EN-US"><span style="mso-list:Ignore">5.<span style="font:7.0pt &quot;Times New Roman&quot;">    </span></span></span><span lang="ES-TRAD" style="font-family:Calibri;mso-bidi-font-family:Arial;color:black;
mso-ansi-language:ES-TRAD;mso-fareast-language:EN-US">Ventura, A.C., Sepulchre,
J.A., and Merajver, S.D. (2008). A hidden feedback in signaling cascades is
revealed. PLoS Comput Biol<i> 4</i>, 14.</span></a><span style="mso-bookmark:
_ENREF_5"></span><span style="font-family:Arial;color:black;mso-fareast-language:
EN-US"></span></p>

<p class="MsoListParagraphCxSpLast" style="margin-bottom:0in;margin-bottom:.0001pt;
mso-add-space:auto;text-indent:-.25in;mso-list:l0 level1 lfo1"><a name="_ENREF_6"><span style="font-family:Arial;mso-fareast-font-family:
Arial;color:black;mso-fareast-language:EN-US"><span style="mso-list:Ignore">6.<span style="font:7.0pt &quot;Times New Roman&quot;">    </span></span></span><span lang="ES-TRAD" style="font-family:Calibri;mso-bidi-font-family:Arial;color:black;
mso-ansi-language:ES-TRAD;mso-fareast-language:EN-US">Yu, R.C., Pesce, C.G.,
Colman-Lerner, A., Lok, L., Pincus, D., Serra, E., Holl, M., Benjamin, K.,
Gordon, A., and Brent, R. (2008). Negative feedback that improves information
transmission in yeast signalling. Nature<i> 456</i>, 755-761.</span></a><span style="mso-bookmark:_ENREF_6"></span><span style="font-family:Arial;color:black;
mso-fareast-language:EN-US"></span></p>

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</span></font></p><p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt"><font class="Apple-style-span" face="Calibri"><span lang="ES-TRAD" style="font-family:Calibri;mso-bidi-font-family:Arial;color:black;
mso-ansi-language:ES-TRAD;mso-fareast-language:EN-US">Alejandro Colman-Lerner</span><span style="font-family:Arial;color:black;mso-fareast-language:EN-US"></span></font></p><font class="Apple-style-span" face="Calibri">

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt"><span lang="ES-TRAD" style="font-family:Calibri;mso-bidi-font-family:Arial;color:black;
mso-ansi-language:ES-TRAD;mso-fareast-language:EN-US">Investigador
Adjunto </span></p><p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt"><span lang="ES-TRAD" style="font-family:Calibri;mso-bidi-font-family:Arial;color:black;
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color:black;mso-fareast-language:EN-US"></span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt"><span lang="ES-TRAD" style="font-family:Calibri;mso-bidi-font-family:Arial;color:black;
mso-ansi-language:ES-TRAD;mso-fareast-language:EN-US">Departamento de
Fisiología, Biología Molecular y Celular</span><span style="font-family:Arial;
color:black;mso-fareast-language:EN-US"></span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt"><span style="font-family:Calibri;mso-bidi-font-family:Arial;color:black;mso-fareast-language:
EN-US">Faculad de Ciencias Exactas y Naturales</span><span style="font-family:
Arial;color:black;mso-fareast-language:EN-US"></span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt"><span lang="ES-TRAD" style="font-family:Calibri;mso-bidi-font-family:Arial;color:black;
mso-ansi-language:ES-TRAD;mso-fareast-language:EN-US">Universidad de Buenos
Aires<br>
Ciudad Universitaria - Pabellon 2 - 2º piso<br>
(C1428EHA) Buenos Aires - Argentina<br>
Tel: 54-11-4-576-3386 /4-576-3368, int 119<br>
FAX: 54-11-4-576-3321</span><span style="font-family:Arial;color:black;
mso-fareast-language:EN-US"></span></p>

</font><p></p><p class="MsoNormal" style="font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-ansi-language:
ES-TRAD;mso-no-proof:yes"><br>
 </span></p>

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<p class="MsoNormal" style="font-family: arial, sans-serif; border-collapse: collapse; "><span style="font-family:Calibri"> </span></p>

<p class="MsoNormal" style="font-family: arial, sans-serif; border-collapse: collapse; "><span lang="ES-TRAD" style="font-family:Calibri;mso-ansi-language:
ES-TRAD"> </span></p>

<br>-- <br>Alejandro Colman-Lerner<br>