[Seminariosifibyne] Ciclo de Seminarios IFIBYNE-FBMC 2022 - AGOSTO

[Comunicación IFIBYNE]

Dentro del ciclo de actividades IFIBYNE 2022 presentamos los próximos
Seminarios organizados por el IFIBYNE y el FBMC que se desarrollaran en
el auditorio del nuevo espacio cultural del Instituto.
Podrán ver la información actualizada en la sección "Seminarios" de la
página web https://ifibyne.fcen.uba.ar/seminarios-2
Contamos con la presencia de toda la comunidad IFIBYNE

VIERNES 12 DE AGOSTO, 12:00 HORAS - AUDITORIO IFIBYNE
Presencial - Seminario Invitados - Ingreso libre con acreditación previa
Coordina: Alejandro Delorenzi
Contacto IFIBYNE: Fernando Locatelli - locatellif at fbmc.fcen.uba.ar
Contacto FBMC: Mariana Feld -  feld.mariana at gmail.com

KENNETH LUKOWIAK
Hotchkiss Brain Institute
Department of Physiology and Pharmacology
University of Calgary, CANADA
https://bit.ly/3SHnny7

"THE MANY FORMS OF MEMORY IN LYMNAEA. WHY WE SHOULD BE INTERESTED IN ALL
OF THEM"

xperiments starting in 1986 demonstrated that long-term memory formation
(LTM, i.e., a memory lasting at least 24h) occurs following operant
conditioning of a very tractable Lymnaea  behaviour -aerial respiration.
Experiments that followed showed that a single neuron was a necessary
site for LTM. It was then shown that even a single event (i.e. one-trial
learning-1TT) using aerial respiration could result in LTM formation. We
went on to show that various ecologically relevant stressors could alter
the formation of LTM and its duration. Some stressors blocked LTM
formation while others enhanced it. Stressors could also alter the
ability to recall a formed LTM, something we did not expect. Using
another tractable behaviour feeding we have now been able to demonstrate
different forms of conditioned taste aversion (CTA). Interestingly, LTM
of CTA can be produced by a single training event. More recently, using
this behaviour we have been able to demonstrate a 'higher form of
learning and memory-Configural Learning (CL). To cause CL Lymnaea
experience a food taste at the same time with a predator scent. Snails
now do not eat the substance they encountered with the predator scent.
More importantly training snails in the scent of the food alters LTM
formation of a behaviour (aerial respiration) that was not encountered
in the CL procedure. Finally, we have now demonstrated a Garcia-effect'
in Lymnaea. When they eat a novel food substance and then are made sick
hours later (either by a heat shock or LPS injection) they now avoid
that food. However, this only works with a novel food taste. We are now,
using the Garcia-effect training procedure to find whether even a 5
minute exposure to a novel food substance is sufficient to produce a LTM
of the new taste such that even 2 weeks later the food-taste is no
longer capable of producing a Garcia-effect Finally, we are now able to
demonstrate changes in the mRNA associated with these various memory
states.

-------------------

VIERNES 19 DE AGOSTO, 12:00 HORAS - AUDITORIO IFIBYNE
Presencial - Seminario Invitados - Ingreso libre con acreditación previa
Coordinan: Valentina Salzman y Esteban Beckwith @esteban_beckwith
Contacto IFIBYNE: vsalzman at iibintech.com.ar - estebanbeck at gmail.com
Contacto FBMC: Mariana Feld -  feld.mariana at gmail.com

ESTEBAN MAZZONI
Department of Biology, Neuroscience Institute, New York University
web: https://www.mazzonilab.org [1]                        

"MECANISMOS DE DIFERENCIACIÓN Y MEMORIA EPIGENÉTICA DE GENES HOX DURANTE
LA DIFERENCIACIÓN CELULAR"

Dos procesos conviven durante la diferenciación de motoneuronas y
generan la variedad de neuronas necesaria para el funcionamiento de la
espina dorsal: rápida regulación génica que guía la diferenciación y una
memoria epigenética estable que mantiene la posición celular eje
anteroposterior. Para entender estos procesos, hemos desarrollado
tecnologías nuevas que combinan la diferenciación de células madres,
screens genéticos y la construcción de elementos genéticos sintéticos de
gran tamaño. Finalmente, utilizamos estos conocimientos para generar
motoneuronas con distinta susceptibilidad a la neurodegeneración para
identificar los mecanismos que protegen a ciertas neuronas de la
degeneración.

-- 
 

Links:
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[1] https://www.mazzonilab.org/
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